human papillomavirus is an important cause of invasive cervical cancer worldwide

 A recent report that 93 percent of invasive cervical cancer worldwide contain human papillomavirus (HPV) may be too low, because the samples are not able or integration events that affect the genes of HPV L1, which is the target of the polymerase chain reaction (PCR) -based tests used , Previous cases of HPV-negative from the study because it has been reviewed to HPV and HPV serum antibody DNA. Serology for HPV 16 VLP, antibody E6, and E7 performed on 49 of the 66 cases were HPV-negative and 48 samples from the 866 HPV-positive cases in the original study. 

In addition, 55 of 66 biopsies previously HPV-negative are also analyzed with procedures bakery where the outer part in a series of parts that used to be examined histologically, while the inside tested by three HPV PCR of different targets the open reading different frames (ORFs) , No significant differences were found in the serology for HPV 16 proteins among cases are initially HPV PCR negative and positive. E7 type-specific PCR for 14 high-risk HPV types HPV DNA was detected in 38 (69 percent) of the 55 originally HPV-negative and amplifiable specimens. HPV types detected are 16, 18, 31, 33, 39, 45, 52, and 58. Two (4 percent) of additional cases only HPV DNA positive by E1 and / or L1 consensus PCR. 

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Histologic analysis of 55 specimens revealed that 21 qualitatively inadequate. Only two of the samples were adequate 34 were HPV-negative in all PCR tests, as against 13 of the 21 were inadequate (p <0.001). Combining data from this and previous studies and excluding inadequate specimens, HPV prevalence worldwide in cervical carcinoma was 99.7 percent. The presence of HPV in virtually all cervical cancers worldwide are caused faction implies the highest so far reported for the specific cause of any major human cancer. Extreme scarcity of HPV-negative cancer strengthened the case for HPV testing in addition to, or even instead of, cervical cytology in routine cervical screening.

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